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The Year in Cell Biology: 2022

Explore our annual collection of the most exciting JCB papers.
Protein homeostasis

Zhao…Dagdas: Autophagosomes sorted at amphisomes in plants.
Cell cycle and division

Dantas…Ferreira: Nuclear tension controls mitotic entry.

New Articles

Article

| December 27 2022

Mechanosensitive RhoGEF activates tissue contraction

Shiri Avivi Kela, Kriti Sethi, Pei Yi Tan, Danesha Suresh, Hui Ting Ong, Perla G. Castaneda, Mustafi R. Amin, Tal Laviv, Erin J. Cram, Jan Faix, Ronen Zaidel-Bar

Avivi Kela et al. discovered a novel mechanotransduction pathway in the C. elegans spermatheca involving tension-dependent localization of a RhoGEF and a positive feedback loop for RHO-1–MyosinII activation that gives an epithelial tube the ability to sense luminal pressure and adjust its contractility in response.

Article

| December 27 2022

Degradation of TNIP1 by selective autophagy

Jianwen Zhou, Nikoline Lander Rasmussen, Hallvard Lauritz Olsvik, Vyacheslav Akimov, Zehan Hu, Gry Evjen, Stéphanie Kaeser-Pebernard, Devanarayanan Siva Sankar, Carole Roubaty, Pauline Verlhac, Nicole van de Beck, Fulvio Reggiori, Yakubu Princely Abudu, Blagoy Blagoev, Trond Lamark, Terje Johansen, Jörn Dengjel

Autophagy is well known for its anti-inflammatory effects. In this article, Zhou, Rasmussen et al. highlight that selective, autophagy-dependent degradation of the inflammation repressor TNIP1 supports pro-inflammatory gene and protein expression. Similarly as in cancer, autophagy appears to play a dual role in controlling inflammation.

Tools

| December 26 2022

Local membrane environments around proteins

Miwa Umebayashi, Satoko Takemoto, Luc Reymond, Mayya Sundukova, Ruud Hovius, Annalisa Bucci, Paul A. Heppenstall, Hideo Yokota, Kai Johnsson, Howard Riezman

We present a method probing the local membrane environment surrounding membrane proteins in the plasma membrane by linking a solvatochromic dye to the target, and provide evidence for lipid-based sorting. The insulin receptor environment changed upon insulin stimulation revealing dynamic local changes and distance dependence.

Article

| December 26 2022

Spatiotemporal regulation of Cdc42 at invadopodia

Gabriel Kreider-Letterman, Abel Castillo, Eike K. Mahlandt, Joachim Goedhart, Agustin Rabino, Silvia Goicoechea, Rafael Garcia-Mata

Kreider-Letterman et al. describe a novel mechanism for the regulation of Cdc42 dynamics at invadopodia by the Cdc42-GAP ARHGAP17, which targets to the invadopodia ring during assembly and relocates to the core to inactivate Cdc42 and initiate disassembly.

Article

| December 23 2022

Septin filaments mediate actin-membrane anchoring

Carla Silva Martins, Cyntia Taveneau, Gerard Castro-Linares, Mikhail Baibakov, Nicolas Buzhinsky, Mar Eroles, Violeta Milanović, Shizue Omi, Jean-Denis Pedelacq, Francois Iv, Léa Bouillard, Alexander Llewellyn, Maxime Gomes, Mayssa Belhabib, Mira Kuzmić, Pascal Verdier-Pinard, Stacey Lee, Ali Badache, Sanjay Kumar, Cristel Chandre, Sophie Brasselet, Felix Rico, Olivier Rossier, Gijsje H. Koenderink, Jerome Wenger, Stéphanie Cabantous, Manos Mavrakis

Martins et al. show that all septins associated with actin stress fibers organize as octamer-based filaments that mediate actin-membrane anchoring. Depleting octamers or preventing septins from polymerizing leads to a partial loss of stress fibers and compromised cell mechanics.

Tools

| December 23 2022

CLEMSite automates correlative light and volume EM

José M. Serra Lleti, Anna M. Steyer, Nicole L. Schieber, Beate Neumann, Christian Tischer, Volker Hilsenstein, Mike Holtstrom, David Unrau, Robert Kirmse, John M. Lucocq, Rainer Pepperkok, Yannick Schwab

Lleti, Steyer, and Schieber et al. present an integrated software that automates correlative light and volume electron microscopy to perform high-resolution volumetric imaging of multiple cells.

Tools

| December 19 2022

ILEE toolbox for cytoskeleton image analysis

Pai Li, Ze Zhang, Yiying Tong, Bardees M. Foda, Brad Day

Li and Zhang et al. present Implicit Laplacian of Enhanced Edge (ILEE), an algorithm and toolbox for unbiased, quantitative, and cytoskeletal image analysis. ILEE solves historical challenges and improves the accuracy, stability, and robustness of cytoskeletal quantification, as well as extending the number of quantifiable cytoskeletal features.

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Explore our annual collection of the most exciting JCB papers.

Zhao…Dagdas: Autophagosomes sorted at amphisomes in plants.

Dantas…Ferreira: Nuclear tension controls mitotic entry.

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Special Collections

Explore our annual collection of the most exciting JCB papers.

Zhao…Dagdas: Autophagosomes sorted at amphisomes in plants.

Dantas…Ferreira: Nuclear tension controls mitotic entry.

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Special Collections

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